Research and Publications

Our areas of research include the surgical treatment of Spasmodic Dysphonia, hemi-laryngopharyngeal spasm (HELPS), Parkinson’s Disease, Multiple Sclerosis, Dystonia, Trigeminal Neuralgia, neuropathic pain, and cancer pain.  A list of our recent publications is provided below.

Funding Support

We have received research funding from the following organizations:

Trigeminal Neuralgia Association of Canada

BC Mental Health Association

Rare Diseases Foundation of BC

Vancouver Coastal Health Research Institute

Canadian Institutes of Health Research

National Spasmodic Dysphonia Association

Our work has also been generously supported by industry grants from Medtronic, Boston Scientific and St. Jude’s Medical.

We are also grateful to the Parkinson’s Society of British Columbia who generously provided the funds to purchase one of our Radionics Lesion Generators and one of our Medtronic LeadPoint microelectrode recording systems. This equipment benefited many of our early surgical patients with Parkinson’s disease, Tremor and Multiple Sclerosis.

Recent Publications

  1. Holtzheimer PE, Husain MM, Lisanby SH, Taylor SF, Whitworth LA, McClintock S, Slavin KV, Berman J, McKhann GM, Patil PG, Rittberg BR, Abosch A, Pandurangi AK, Holloway KL, Lam RW, Honey CR, Neimat JS, Henderson JM, DeBattista C, Rothschild AJ, Pilitsis JG, Espinoza RT, Petrides G, Mogilner AY, Matthews K, Peichel D, Gross RE, Hamani C, Lozano AM, Mayberg HS. Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomized, sham-controlled trial.
    Lancet Psychiatry (2017)doi: 10.1016/S2215-0366(17)30371-1.
  2. Ivanishvili Z, Poologaindran A, Honey CR. Cyclization of motor cortex stimulation for neuropathic pain: a prospective, randomized, blinded trial.
    Neuromodulation (2017) 20: 497-503.
  3. Poologaindran A, Ivanishvili Z, Morrison MD, Rammage LA, Sandhu MK, Polyhrondopoulos NE, Honey CR.  The effect of unilateral thalamic deep brain stimulation on the vocal dysfunction of a patient with spasmodic dysphonia: interrogating cerebellar and pallidal neural circuits.
    Journal of Neurosurgery (2017) 17:1-8.
  4. Panisset M, Picillo M, Jodoin N, Poon YY, Valencia-Mizrachi A, Fasano A, Munhoz R, Honey CR. Establishing a standard of care for deep brain stimulation centres in Canada.
    Journal of Neurological Science (2016) 22:1-7.
  5. Fasano A, Appel-Cresswell S, Jog M, Zurowkski M, Duff-Canning S, Cohn M, Picillo M, Honey CR, Panisset M, Munhoz RP. Medical Management of Parkinson’s Disease after Initiation of Deep Brain Stimulation.
    Journal of Neurological Sciences (2016) 43:626-634.
  6. Honey CM, Tronnier VM, Honey CR. Deep brain stimulation versus motor cortex stimulation for neuropathic pain: A minireview of the literature and proposal for future research.
    and Structural Biotechnology Journal (2016) 16:234-237.
  7. Honey CR, Gooderham P, Morrison M, Ivanishvili Z. Episodic hemilaryngopharyngeal spasm (HELPS) syndrome: case report of a surgically treatable novel neuropathy.
    Journal of Neurosurgery (2016) 8:1-4.
  8. Munhoz RP, Picillo M, Fox SH, Bruno V, Panisset M, Honey CR, Fasano A. Eligibility Criteria for Deep Brain Stimulation in Parkinson’s Disease, Tremor, and Dystonia.
    Journal of Neurological Sciences (2016) 43:462-471.
  9. Coenen VA, Jenkner C, Honey CR, Madler B. Electrophysiologic validation of diffusion tensor imaging tractography during deep brain stimulation surgery.
    Journal of Neuradiology (2016) 37:1470-1478.
  10. Honey CR, Hamani C, Kalia SK, Sankar T, Picillo M, Munhoz RP, Fasano A, Panisset M. Deep Brain Stimulation target selection for Parkinson’s disease.
    Journal of Neurological Sciences (2016) 44:3-8.
  11. Ivanishvili Z, Puram S, Honey CM, Chang S, Honey CR. Stereotactic mesencephalotomy for palliative care pain controll A case report, literature review and plea to rediscover this operation.
    Journal of Neurosurgery (2016) 30:444-447.
  12. Moro E, Schupbach M, Wachter T, Allert N, Eleopra A, Honey CR, Rueda M, Schiess MC, Shimo Y, Valkovic P, Whone A, Stoevelaar H. Referring Parkinson’s disease patients for deep brain stimulation: a RAND/UCLA appropriateness study.
    Journal of Neurology (2015) 263: 112-119.
  13. Slotty PJ, Chang S, Honey CR. Motor threshold: a possible guide to optimizing stimulation parameters for motor cortex stimulation.
    Neuromodulation (2015) 18: 566-571.
  14. Slotty PJ, Poologaindran A, Honey CR. A prospective, randomized, blinded assessment of multitarget thalamic and pallidal deep brain stimulation in a case of hemidystonia.
    Clinical Neurology and Neurosurgery (2015) 138: 16-19.
  15. Schutz PW, Honey CR, Yip S. 35-Year-Old Man with Lytic Skull Lesion. Langerhans Cell Histiocytosis (LCH).
    Brain Pathology (2015) 25:367-368.
  16. Slotty PJ, Eisner W, Honey CR, Wille C, Vesper J. Long-term follow-up of motor cortex stimulation for neuropathic pain in 23 patients.
    Stereotactic and  Functional Neurosurgery (2015) 93: 199-205.
  17. Chang S, Slotty PJ, Honey CR. The
    Influence of Positioning and Muscle Activity on Motor Threshold during Motor Cortex Stimulation Programming. 
    Stereotactic and Functional Neurosurgery (2015) 93: 122-126.
  18. Fasano A, Aquino CC, Krauss JK, Honey CR, Bloem BR. Axial disability and deep brain stimulation in patients with Parkinson disease.
    Nature Revues Neurology (2015) 11: 98-110. 
  19. van Karnebeek C, Horvath G, Murphy T, Purtzki J, Bowden K, Sirrs S, Honey CR, Stockler S. Deep Brain Stimulation and Dantrolene for Secondary Dystonia in X-Linked Adrenoleukodystrophy.
    Journal of Inherited Metabolic Disease Reports (2015) 15: 113-116.
  20. Bogod NM, Sinden N, Woo C, Defreites VG, Torres IJ, Howard AK, Ilcewicz-Klimek MI, Honey CR, Yatham LN, Lam RW. Long-term neuropsychological safety of subgenual cingulate gyrus deep brain stimulation for treatment-resistant depression.
    Journal of Neuropsychiatry and Clinical Neuroscience (2014) 26: 126-233.
  21. Honey CR, Yeomans W, Isaacs A, Honey CM. The dying art of percutaneous cordotomy in Canada.
    Journal of Palliative Medicine (2014) 17: 624-628.
  22. Vila-Rodriguez F, McGirr A, Tham J, Hadjipavlou G, Honey CR. Electroconvulsive Therapy in Patients With Deep Brain Stimulators.
    Journal of ECT (2014) 30(3): e16-18.
  23. Lehman AM, Dong CC, Harries AM, Patel A, Honey CR, Patel MS.  Evidence of ancillary trigeminal innervation of levator palpebrae in the general population.
    Journal of Clinical Neuroscience (2014) 21: 301-304.
  24. Harries AM, Sandhu M, Spacey SD, Aly MM, Honey CR. Unilateral pallidal deep brain stimulation in a patient with dystonia secondary to episodic ataxia type 2.
    Stereotactic and Functional Neurosurgery (2013) 91: 233-235.
  25. Ranjan M, Dupre C, Honey CR., Trigeminal neuralgia secondary to giant Virchow-Robin spaces: a case report with neuroimaging.
    Pain (2013) 154: 617-619.
  26. Mendelsohn D, Ranjan M, Hawley P, Honey CR., Percutaneous Trigeminal Rhizotomy for Facial Pain Secondary to Head and Neck Malignancy.
    Clinical Journal of Pain (2013) 29(10): e4-5.
  27. Honey CR. and Ranjan M., Deep Brain Stimulation for Parkinson’s Disease—A Review.
    Touch Briefings (2012) US Neurology 12-19.
  28. Hurwitz TA, Honey CR, Allen J, Gosselin C, Hewko R, Martzke J, Bogod N, Taylor P. Bilateral anterior capsulotomy for intractable depression.
    Journal of Neuropsychiatry and Clinical Neuroscience (2012) 24: 176-82.
  29. Harries AM, Dong CC, Honey CR. Use of endotracheal tube electrodes in treating glossopharyngeal neuralgia: technical note.
    Stereotactic and Functional Neurosurgery (2012) 90: 141-144.
  30. Howard A, Honey CR, Hurwitz TA, Ilcewicz-Klimek M, Woo C, Lam RW, Berman N. Deep brain stimulation interruption and suicidality.
    Journal of Neurosurgery (2012) 116: 467-468.
  31. Lozano AM, Giacobbe P, Hamani C, Rizvi SJ, Kennedy SH, Kolivakis TT, Debonnel G, Sadikot AF, Lam RW, Howard AK, Ilcewicz-Klimek M, Honey CR, Mayberg HS. A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression.
    Journal of Neurosurgery (2012) 116: 315-322.
  32. Harries AM, Major S, Sandhu M, Honey CR. Rechargeable internal neural stimulators–is there a problem with efficacy?
    Neuromodulation (2012) 15: 214-217; discussion 217-218.
  33. Rose NG, Mostrenko M, McMaster J, Honey CR. Severe agitation following deep brain stimulation for parkinsonism.
    Canadian Journal of Emergency Medicine (2011) 13(4): 279-83, E11-2.
  34. Simms HN, Honey CR. The importance of autonomic symptoms in trigeminal neuralgia. Clinical article.
    Journal of Neurosurgery (2011) 115: 210-216.
  35. Coenen VA, Honey CR, Hurwitz T, Rahman AA, McMaster J, Bürgel U, Mädler B. Medial forebrain bundle stimulation as a pathophysiological mechanism for hypomania in subthalamic nucleus deep brain stimulation for Parkinson’s disease.
    Neurosurgery (2009) 64: 1106-1114.
  36. Vertinsky AT, Coenen VA, Lang DJ, Kolind S, Honey CR, Li D, Rauscher A. Localization of the subthalamic nucleus: optimization with susceptibility-weighted phase MR imaging.
    American Journal of Neuroradiology (2009) 30: 1717-1724.
  37. Moore GR, Vitali AM, Leung E, Laule C, Kozlowski P, Mackay AL, Honey CR. Thalamic stimulation in multiple sclerosis: evidence for a ‘demyelinative thalamotomy’.
    Multiple Sclerosis (2009) 15: 1311-1321.
  38. McMaster J, Gibson G, Castro-Prado F, Vitali A, Honey CR. Neurosurgical treatment of tremor in anti-myelin-associated glycoprotein neuropathy.
    Neurology (2009) 73: 1707-1708.
  39. Bürgel U, Mädler B, Honey CR, Thron A, Gilsbach J, Coenen VA. Fiber tracking with distinct software tools results in a clear diversity in anatomical fiber tract portrayal.
    Central European Neurosurgery (2009) 70: 27-35.
  40. Sayer FT, Vitali AM, Paquette S, Honey CR. Isolated C3-C4 disc herniations present as a painless myelopathy.
    Spine Journal (2008) 8: 729-731.
  41. Low HL, Sayer FT, Honey CR. Pathological crying caused by high-frequency stimulation in the region of the caudal internal capsule. Archives of Neurology (2008) 65: 264-266.
  42. Sayer FT, Vitali AM, Low HL, Paquette S, Honey CR. Brown-Sèquard syndrome produced by C3-C4 cervical disc herniation: a case report and review of the literature.
    Spine (2008) 33: 279-282.
  43. Coenen VA, Gielen FL, Castro-Prado F, Abdel Rahman A, Honey CR. Noradrenergic modulation of subthalamic nucleus activity in human: metoprolol reduces spiking activity in microelectrode recordings during deep brain stimulation surgery for Parkinson’s disease.
    Acta Neurochirugica (2008) 150: 757-762.
  44. Low HL, Honey CR. Focal childhood-onset, action induced primary hip dystonia treated with pallidal deep brain stimulation.
    Movement Disorders (2008) 23: 1926-1928.
  45. Vitali AM, Sayer FT, Honey CR. Recurrent trigeminal neuralgia secondary to Teflon felt.
    Acta Neurochirurgica (2007) 149: 719-722.
  46. Hurwitz TA, Mandat T, Foster B, Honey C. Tract identification by novel MRI signal changes following stereotactic anterior capsulotomy.
    Stereotactic and Functional Neurosurgery (2006) 84: 228-235.
  47. Mercado R, Mandat T, Moore GRW, Li D, MacKay A, Honey CR. 3T MRI of the ventrolateral thalamus: a correlative anatomical description.
    Journal of Neurosurgery (2006) 105(2): 279-283.
  48. Mercado R, Constantoyannis C, Mandat T, Kumar A, Schulzer M, Stoessl J, Honey CR. Expectation and the placebo effect in Parkinson’s disease patients with subthalamic nucleus deep brain stimulation.
    Movement Disorders (2006) 21: 1457-1461.
  49. Mandat TS, Hurwitz T, Honey CR. Hypomania as an adverse effect of subthalamic nucleus stimulation: report of two cases.
    Acta Neurochirurgica (2006) 148: 895-897.
  50. Constantoyannis C, Berk C, Honey CR, Mendez I, Brownstone RM. Reducing hardware-related complications of deep brain stimulation.
    Canadian Journal of Neurological Sciences (2005) 32: 194-200.
  51. Mandat TS, Honey CR, Peters DA, Sharma BR. Artistic assault: an unusual penetrating head injury reported as a trivial facial trauma.
    Acta Neurochirurgica (2005) 147: 331-333.
  52. Sun DA, Martin L, Honey CR. Percutaneous radiofrequency trigeminal rhizotomy in a patient with an implanted cardiac pacemaker.
    Anesthesia & Analgesia (2004) 99: 1585-1586.
  53. Doudet DJ, Cornfeldt ML, Honey CR, Schweikert AW, Allen RC. PET Imaging of Implanted Human Retinal Pigment Epithelial (hRPE) Cells in the MPTP induced Primate Model of Parkinson’s Disease.
    Experimental Neurology (2004) 189: 361-368.
  54. Constantoyannis C, Kumar A, Stoessl J, Honey CR. Tremor induced by thalamic deep brain stimulation in patients with complex regional facial pain.
    Movement Disorders (2004) 19: 933-936.
  55. Constantoyannis C, Heilbron B, Honey CR. Electrocardiogram artifacts caused by deep brain stimulation.
    Canadian Journal of Neurological Sciences (2004) 31: 343-346.
  56. Griesdale D and Honey CR. Aquaporins and brain edema.
    Surgical Neurology (2004) 61: 418-421.
  57. Watts RL, Raiser CD, Stover NP, Cornfeldt ML, Schweikert AW, Allen RC, Subramanian T, Doudet D, Honey CR, Bakay RAE. Stereotaxic intrastriatal implantation of human retinal pigment epithelial (hRPE) cells attached to gelatin microcarriers: a potential new cell therapy for Parkinson’s disease.
    Journal of Neural Transmission (2003) 65: 215-227.
  58. Gusmao S, Oliveira M, Tazinafo U, Honey CR. Percutaneous trigeminal nerve radiofrequency rhizotomy guided by real time computed tomography: description of a new technique.
    Journal of Neurosurgery. (2003) 99: 785-786.
  59. Heran NS, Berk C, Constantoyannis C, Honey CR. Neuroepithelial cysts presenting with movement disorders. A report of two cases.
    Canadian Journal of Neurological Sciences. (2003) 30: 393-396.
  60. Berk C, Constantoyannis C, Honey CR. The treatment of trigeminal neuralgia in patients with multiple sclerosis using percutaneous radiofrequency rhizotomy.
    Canadian Journal of Neurological Sciences (2003) 30: 220-223.
  61. Carr JAR, Honey CR, Sinden M, Phillips AG, Martzke JS. A waitlist control group study of cognitive, mood, and quality of life outcome from posteroventral pallidotomy in Parkinson’s disease.
    Journal of Neurosurgery (2003) 99: 78-88.
  62. Sun M-C, Honey CR, Berk C, Wong NLM, Tsui JKC. Regulation of aquaporin-4 in a traumatic brain injury model.
    Journal of Neurosurgery (2003) 98: 565-569.
  63. Berk C, Carr J, Sinden M, Martzke J, Honey CR. Thalamic deep brain stimulation for the tremor of multiple sclerosis: a prospective study of tremor and quality of life.
    Journal of Neurosurgery (2002) 47: 815-820.
  64. Berk C and Honey CR. Percutaneous biopsy through the foramen oval.
    Stereotactic and Functional Neurosurgery (2002) 78: 49-52.
  65. Palur RS, Berk C, Schulzer M, Honey CR. A meta-analysis comparing the results of pallidotomy performed with microelectrode recording or macroelectrode stimulation.
    Journal of Neurosurgery (2002) 96: 1058-1062.
  66. Berk C and Honey CR: Bilateral thalamic deep brain stimulation for head tremor.
    Journal of Neurosurgery (2002) 96: 615-618.
  67. Murphy TH, Yu J, Ng R, Johnson DA, Shen H, Honey CR, Johnson JA. Preferential expression of antioxidane response element mediated gene expression in astrocytes.
    Journal of Neurochemistry (2001) 76: 1670-1678.
  68. Laxton AW, Sun MC, Shen H, Murphy TH, Honey CR. The antioxidant enzyme quinone reductase is up-regulated in vivo following cerebral ischemia.
    NeuroReport (2001) 12: 1045-1048.
  69. Honey CR and Palur RS. Surgery for Parkinson’s Disease.
    British Columbia Medical Journal (2001) 43: 210-213.